Depends on the drive, some have various options as well as Ethernet to work over the LAN. Some do some don't, normally the more expensive ones do ;)...
If its a fresh install ( reinstall fresh) then a non compliant Machine will still be non compliant. You will be able to install W11 from scratch, no...
If its a private Server ( not a Microsoft Server -Outlook) then you have to make sure all settings, SSL, Authentication, actual mail server names and...