The Antec threehundred and twelvehunderd have a ground loop problem with the front panel audio. I've had the same issue with the twelvehundred, damn stupid design, the engineer who thought earthing the audio with the USBs was a good idea should be hung.
Fortunately for you the threehundred is a heap easier to get at than the twelvehundred.
See here for the fix.
http://forums.bit-tech.net/showthread.php?t=208880
http://www.incrysis.com/forums/viewtopic.php?id=29778
http://forums.overclockers.com.au/sh...php?p=11145597



, after reading those instructions about the wire -- I cant help but think of

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